A Brief Discussion about Lithium Orotate
Lithium orotate at https://www.cofttek.com/product/5266-20-6/ counted as a lithium supplement in the hybrid of orotic acid and lithium, beneficial to the relief of bipolar disorders, mania, distress, sadness, and brain health, etc.Basically, lithium is a naturally existing trace element that could not survive alone, and it has to be in the salt form with other ingredients. It is a lithium compound popular among supplement users.
There are already various lithium salts on the market. These include lithium carbonate, lithium aspartate, and lithium chloride. It is 98% pure. The molecular weight is 160.0297 g/mole. The melting point is greater than or equal to 300°C. Chemically pronounced as orotic acid lithium salt monohydrate. It readily gets soluble in DMSO, Water, and Methanol. We can store it under 0-4 C for the brief term, or -20 C for the long term. It is a white powder.
Lithium orotate: Benefits
We have also used it has also with success in alleviating the pain from migraine and cluster headaches, low white blood cell counts, juvenile convulsive disease, alcoholism, and liver disorders.
And also noted that patients with myopia and glaucoma often enjoy the minor dehydrating effect of lithium on the eye, concluding in restoration in vision and lessening of interocular pressure.
Lithium orotate: Mechanism of Action
Lithium orotatereleases lithium-ion into the plasma and brain much like pharmaceutical lithium carbonate and citrate. This is much a similar manner prescription lithium works, although with no toxicity.
It deals with bipolar unpredictability by heightening the uptake of two exciting chemicals (dopamine and norepinephrine) into synaptosomes. Synaptosomes are squeezed off nerve being that can’t release hormones. This can help individuals to stay calm once they would not be.
Lithium will the signaling of among the D2 dopamine receptors within the brain. Expanded dopamine results in individuals to behave impulsively and occasionally. Lithium orotate, citrate, carbonate also restricts the glycogen synthase kinase 3 (GSK-3) enzyme crucial in the cell’s response to many signaling molecules.
Mania is reduced by destabilizing the D2/GSK3 signaling path complex.
Lithium orotate: Applications
It is a substance that comprises lithium and orotic acid. It is accessible in dietary supplement form, we praise lithium orotate as a natural treatment for a broad spectrum of mental health problems.
Lithium orotate: Effectiveness
Under the light of reports by Nieper in 1973, lithium orotate comprised 3.83 mg of elemental lithium/100 mg, and lithium carbonate comprised 18.83 mg of elemental lithium/100 mg. He claimed that lithium did not dissolve from the orotate carrier until it passed through the blood-brain barrier.
Lithium orotate: Side Effects and Safety
There is no proper research material available. It may have some toxic effects. It is concerned that its use may lower kidney function.It may cause adverse effects like Magnesium L-threonate . Other than nausea and vomiting, cardiac arrhythmias, and neurological problems may be recorded. Confusion, coma, kidney failure, and occasionally death may occur because of severe toxicity.